Food and Drug Administration (FDA) has lifted a partial clinical hold. CDK2 in complex with CCNE1 phosphorylates Rb, resulting in E2F target gene expression and G1 to S-phase cell cycle progression. (ASCO 2023) - P1/2 'One partial response was seen in a pt with HR+/HER2 metastatic breast cancer previously treated with 5 lines of therapy, including palbociclib, abemaciclib, and capecitabine. This allows us to measure and analyse the performance of our services.īy cookies you give consent to the processing of your personal data, including transfer to third parties. Further information can be found in our privacy policy. CAMBRIDGE, Mass., Ma/PRNewswire/ - Blueprint Medicines Corporation (NASDAQ: BPMC) today announced that the U.S. BLU-222, an oral, potent, and selective CDK2 inhibitor, in patients with advanced solid tumors: Phase 1 monotherapy dose escalation. Keeping track of items stored in your shopping basket and personal cabinet.Ĭonducting research and diagnostics to improve ChemDiv’s content, products, and services.ĭelivering content, including ads, relevant to your interests on ChemDiv’s site You may set your preferences through Your Account. Keeping track of your specified preferences. This allows us to provide you with product recommendations, display personalised content, and provide other customised features and services.
#BLUEPRINT CDK2 TRIAL#
Recognising you when you sign-in to use our services. The FDA has lifted the partial clinical hold previously placed on the phase 1/2 VELA trial (NCT05252416) evaluating BLU-222, a selective inhibitor of CDK2, as a treatment for patients with solid tumors. We use "cookies* to ensure the functionality of our website, recognise your browser or device, learn more about your interests, and provide you with essential features and services and for additional purposes, including:
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